Analysis performed on 2024-09-30 10:30:02
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 20031 | 265 | 19766 | 11532 |
| Archaea | 1501 | 31 | 1470 | 556 |
| Vertebrata | 761 | 243 | 518 | 352 |
| Mammals | 295 | 42 | 253 | 128 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 775 | 26 | 801 |
| Domains | |
|---|---|
| Current Study | 1, 166 |
| Guo et al (2010) | 1, 260 |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 610 | 165 | 775 | 3.696970 |
| Number of Variants | 639 | 188 | 827 | 3.398936 |
| Number of Pathogenic Variants | 20 | 6 | 26 | 3.333333 |
| Number of Benign/Unknown Variants | 619 | 182 | 801 | 3.401099 |
| Fisher exact test | 1.000000 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 515 | 260 | 775 | 1.980769 |
| Number of Variants | 535 | 292 | 827 | 1.832192 |
| Number of Pathogenic Variants | 20 | 6 | 26 | 3.333333 |
| Number of Benign/Unknown Variants | 515 | 286 | 801 | 1.800699 |
| Fisher exact test | 0.215644 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 610 | 165 | 0.90 (0.01) | 0.81 (0.01) | 9.753e-01 | 8.895e-01 | 71845.00 | 1.56e-17 |
| Guo et al (2010) | 515 | 260 | 0.91 (0.01) | 0.82 (0.01) | 9.840e-01 | 9.179e-01 | 95734.50 | 6.21e-23 |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.